Publications
Most Relevant Publications
Cinti S, Singh S, Covone G, Tonietti L, Ricciardelli A, Cordone A, Iacono R, Mazzoli A, Moracci M, Rotundi A, Giovannelli D. Reviewing the state of biosensors and lab-on-a- chip technologies: opportunities for extreme environments and space exploration. Front Microbiol. 2023 Aug 17;14:1215529. doi: 10.3389/fmicb.2023.1215529
Curci N, Iacono R, Segura DR, Cillo M, Cobucci-Ponzano B, Strazzulli A, Leonardi A, Giger L, Moracci M. Novel GH109 enzymes for bioconversion of group A red blood cells to the universal donor group O. N Biotechnol. 2023 Nov 25;77:130-138. doi: 10.1016/j.nbt.2023.08.002
Awala SI, Gwak JH, Kim Y, Seo C, Strazzulli A, Kim SG, Rhee SK. Methylacidiphilum caldifontis</i> gen. nov., sp. nov., a thermoacidophilic methane-oxidizing bacterium from an acidic geothermal environment, and descriptions of the family <i>Methylacidiphilaceae</i> fam. nov. and order Methylacidiphilales ord. nov. Int J Syst Evol Microbiol. 2023 Oct;73(10). doi: 10.1099/ijsem.0.006085
Iacono R., De Lise F., Moracci M., Cobucci-Ponzano B., Strazzulli A. Glycoside hydrolases from (hyper)thermophilic archaea: structure, function, and applications. Essays Biochem 2023; EBC20220196. doi: https://doi.org/10.1042/EBC20220196
De Lise, F., Iacono, R., Moracci, M., Strazzulli, A., Cobucci-Ponzano, B. Archaea as a Model System for Molecular Biology and Biotechnology. Biomolecules, 2023, 13(1), doi: 10.3390/biom13010114
Iacono R, Strazzulli A, Giglio R, Bitetti F, Cobucci-Ponzano B, Moracci M. Valorization of Biomasses from Energy Crops for the Discovery of Novel Thermophilic Glycoside Hydrolases through Metagenomic Analysis. Int J Mol Sci. 2022 Sep 10;23(18):10505. doi: 10.3390/ijms231810505
2021 Iacono R, Minopoli N, Ferrara MC, Tarallo A, Damiano C, Porto C, Strollo S, Roig-Zamboni V, Peluso G, Sulzenbacher G, Cobucci-Ponzano B, Parenti G, Moracci M. Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase. J Enzyme Inhib MedChem. doi: 10.1080/14756366.2021.1975694
2021 De Lise F., Strazzulli A., Iacono R., Curci N., Di Fenza M., Maurelli L., Moracci M., Cobucci-Ponzano B.Programmed Deviations of Ribosomes From Standard Decoding in Archaea. Frontiers in MicrobiologyDOI 10.3389/fmicb.2021.688061
2021 De Lise F., Iacono R., Strazzulli A., Giglio R., Curci N., Maurelli L., Avino R., Carandente A., Caliro S., Tortora A., Lorenzini F., Di Donato P., Moracci M., Cobucci-Ponzano B. Transcriptregulation of the recoded archaeal α-L-fucosidase in vivo Molecules DOI 10.3390/molecules26071861
2021 Curci N., Strazzulli A., Iacono R., De Lise F., Maurelli L., Di Fenza M., Cobucci‐Ponzano B., Moracci M. Xyloglucan oligosaccharides hydrolysis by exo-acting glycoside hydrolases from hyperthermophilic microorganism Saccharolobus solfataricus. International Journal of MolecularSciences DOI 10.3390/ijms22073325
2021 Iacono R., Minopoli N., Ferrara M.C., Tarallo A., Damiano C., Porto C., Strollo S., Roig-Zamboni V., Peluso G., Sulzenbacher G., Cobucci-Ponzano B., Parenti G., Moracci M. Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase. Journal of Enzyme Inhibition and Medicinal Chemistry DOI 10.1080/14756366.2021.1975694
Awala SI, Gwak JH, Kim YM, Kim SJ, Strazzulli A, Dunfield PF, Yoon H, Kim GJ, Rhee SK. Verrucomicrobial methanotrophs grow on diverse C3 compounds and use a homolog of particulate methane monooxygenase to oxidize acetone. ISME J. 2021 Dec; 15(12):3636-3647. doi: 10.1038/s41396-021-01037-2
Tarallo A, Damiano C, Strollo S, Minopoli N, Indrieri A, Polishchuk E, Zappa F, Nusco E, Fecarotta S, Porto C, Coletta M, Iacono R, Moracci M, Polishchuk R, Medina DL, Imbimbo P, Monti DM, De Matteis MA, Parenti G (2021) Correction of oxidative stress enhances enzyme replacement therapy in Pompe disease, EMBO Molecular Medicine. doi: 10.15252/emmm.202114434
Hamoudi H, Giacobbe S, Strazzulli A, Pezzella C, Sannia G, Moracci M, Piscitelli A, Kecha M,A novel Streptomyces strain isolated by functional bioprospecting for laccases, Process Biochemistry, 2021, Volume 111, Part 2, Pages 315-324, doi: 10.1016/j.procbio.2021.11.016
De Lise F, Iacono R, Strazzulli A, Giglio R, Curci N, Maurelli L, Avino R, Carandente A, Caliro S, Tortora A, Lorenzini F, Di Donato P, Moracci M, Cobucci-Ponzano B. Transcript Regulation of the Recoded Archaeal α-L-Fucosidase In Vivo. Molecules. 2021, 26(7):1861. doi: 10.3390/molecules26071861
Curci N, Strazzulli A, Iacono R, De Lise F, Maurelli M, Di Fenza M, Cobucci‐Ponzano B, and Moracci M (2021) Xyloglucan Oligosaccharides Hydrolysis by Exo‐Acting Glycoside Hydrolases from Hyperthermophilic Microorganism Saccharolobus solfataricus International Journal of Molecular Sciences, 22, 3325. https://doi.org/10.3390/ijms22073325
Iacono I, Minopoli N , Ferrara MC, Tarallo A, Damiano C, Porto C, Strollo S, Roig-Zamboni V, Peluso P, Sulzenbacher G, Cobucci-Ponzano B, Parenti G, and Moracci M. (2021) Carnitine is a pharmacological allosteric chaperone of the human lysosomal α-glucosidase, Journal of Enzyme Inhibition and Medicinal Chemistry. 36 (1), 2068. https://doi.org/10.1080/14756366.2021.1975694
Strazzulli, A, De Lise, F., Iacono, R., Curci N., Maurelli, L., Cobucci Ponzano, B., Moracci, M. Extremophilic Archaea in Astrobiology. Memorie della Societa Astronomica Italiana - Journal of the Italian Astronomical Society, 2021, 92(2), pp. 53–59 doi: 10.1007/s00792-019-01126-3
Aulitto M, Strazzulli A, Sansone F, Cozzolino F, Monti M, Moracci M, Fiorentino G, Limauro D, Bartolucci S, Contursi P. Prebiotic properties of Bacillus coagulans MA-13: production of galactoside hydrolyzing enzymes and characterization of the transglycosylation properties of a GH42 β-galactosidase.Microb Cell Fact. 2021 Mar 18;20(1):71. doi: 10.1186/s12934-021-01553-y
2020 Iacono R., Cobucci-Ponzano B., de Lise F., Curci N., Maurelli L., Moracci M., Strazzulli A. Spatial Metagenomics of Three Geothermal Sites in Pisciarelli Hot Spring Focusing on the Biochemical Resources of the Microbial ConsortiaMolecules DOI 10.3390/molecules25174023
2020 Onofri S., Balucani N., Barone V., Benedetti P., Billi D., Balbi A., Brucato J.R., Cobucci-Ponzano B., et al. The Italian National Project of Astrobiology - Life in Space - Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles. Astrobiology DOI 10.1089/ast.2020.2247
2020 Strazzulli A., Cobucci-Ponzano B., Iacono R., Giglio R., Maurelli L., Curci N., Schiano-di-Cola C., Santangelo A., Contursi P., Lombard V., Henrissat B., Lauro F.M., Fontes C.M.G.A., Moracci M. Discovery of hyperstable carbohydrate-active enzymes throughmetagenomics of extreme environmentsFEBS JournalDOI 10.1111/febs.15080
Iacono R, Cobucci-Ponzano B, De Lise F, Curci N, Maurelli L, Moracci M, Strazzulli A. (2020) Spatial Metagenomics of Three Geothermal Sites in Pisciarelli Hot Spring Focusing on the Biochemical Resources of the Microbial Consortia. Molecules. Sep 3;25(17):4023. doi: 10.3390/molecules25174023
Onofri S, Balucani N, Barone V, Benedetti P, Billi D, Balbi A, Brucato JR, Cobucci-Ponzano B, Costanzo G, Rocca N, Moracci M, Saladino R, Vladilo G; OPPS Project Team. The Italian National Project of Astrobiology-Life in Space-Origin, Presence, Persistence of Life in Space, from Molecules to Extremophiles. Astrobiology. 2020 May;20(5):580-582. doi: 10.1089/ast.2020.2247
Strazzulli, A; Cobucci-Ponzano, B; Iacono, R; Giglio, R; Maurelli, L; Curci, N; Schiano-di-Cola, C; Santangelo, A; Contursi, P; Lombard, V; Henrissat, B; Lauro, FM; Fontes, CMGA; Moracci, M (2019) Discovery of hyperstable carbohydrate-active enzymes through metagenomics of extreme environments The FEBS Journal DOI: 10.1111/febs.15080
Iacono R, Strazzulli A, Maurelli L, Curci N, Casillo A, Corsaro MM, Moracci M, Cobucci-Ponzano B. GlcNAc De-N-Acetylase from the Hyperthermophilic Archaeon Sulfolobus solfataricus (2019) Applied Environmental Microbiology, 85, pii: e01879-18. doi: 10.1128/AEM.01879-18
2019 Giangrieco I., Ricciardi T., Alessandri C., Farina L., Crescenzo R., Tuppo L., Ciancamerla M., Rafaiani C., Bernardi M.L., Digilio A.F., Cobucci-Ponzano B., Tamburrini M., Mari A., Ciardiello M.A. ENEA, a peach and apricot IgE-binding protein cross-reacting with the latex major allergen Hev b 5. Molecular Immunology DOI 10.1016/j.molimm.2019.05.007
2019 Curci N., Strazzulli A., De Lise F., Iacono R., Maurelli L., Dal Piaz F., Cobucci-Ponzano B., Moracci M. Identification of a novel esterase from the thermophilic bacterium Geobacillusthermodenitrificans NG80-2Extremophiles DOI 10.1007/s00792-019-01093-9
Roig-Zamboni V., Cobucci-Ponzano B., Iacono R., Ferrara M.C., Germany S., Bourne Y., Parenti G., Moracci M. and Sulzenbacher G. (2017) Structure of human lysosomal acid-α-glucosidase – a guide for the treatment of Pompe disease. Nature Communications, 8, 1111, doi: 10.1038/s41467-017-01263-3
Tshililo N.O., Strazzulli A., Cobucci-Ponzano B., Maurelli L., Iacono R., Bedini E., Corsaro M.M., Strauss E.*, and Moracci M.* (2017) The α-thioglycoligase derived from a GH89 α-N-acetylglucosaminidase synthesizes α-N-acetylglucosamine-based glycosides of biomedical interest. Advanced Synthesis & Catalysis, 359, 663-676. DOI 10.1002/adsc.201601091
Ferrara M.C., Cobucci-Ponzano B., Carpentieri A., Henrissat B., Rossi M., Amoresano A., Moracci M*. (2014) The identification and molecular characterization of the first archaeal bifunctional exo-β-glucosidase/N-acetyl-β-glucosaminidase demonstrates that family GH116 is made of three functionally distinct subfamilies. Biochim Biophys Acta. 1840, 367-377 doi:10.1016/j.bbagen.2013.09.022
d'Ischia, M., Manini, P., Moracci, M., Saladino, R., Ball, V., Thissen, H., Evans, R.A., Puzzarini, C., Barone, V. (2019) Astrochemistry and Astrobiology: Materials Science in Wonderland? International journal of molecular sciences. 20, 17. Doi: 10.3390/ijms20174079
Aulitto M, Fusco S, Franzén C, Strazzulli A, Moracci M, Bartolucci S, and Contursi P (2019) Draft genome sequence of Bacillus coagulans MA-13: a robust thermophilic lactic acid producer from lignocellulose. Microbiology Resource Announcements; doi:
Perugino G, Strazzulli A, Mazzone M, Rossi M and Moracci M* (2019) Effects of Random Mutagenesis and In Vivo Selection on the Specificity and Stability of a Thermozyme. Catalysts, 9, 440; doi:10.3390/catal9050440
Strazzulli A, Perugino G, Mazzone M, Rossi M, Withers SG, and Moracci M* (2019) Probing the role of an invariant active site His in family GH1 β-glycosidases. Journal of Enzyme Inhibition and Medicinal Chemistry, doi:10.1080/14756366.2019.1608198
Botta L, Saladino R, Bizzarri BM, Cobucci-Ponzano B, Iacono R, Avino R, Caliro, S; Carandente A, Lorenzini F, Tortora A, Di Mauro E, Moracci M, Formamide-based prebiotic chemistry in the Phlegrean Fields (2018) Advances in Space Research, 62, 2372-2379. DOI: 10.1016/j.asr.2017.07.017
Abbot W,….Moracci M…. 101 authors. Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes (2018) Glycobiology, 28, 3-8, DOI:10.1093/glycob/cwx089
Mensitieri F, De Lise F, Strazzulli A, Moracci M, Notomista E, Cafaro V, Bedini E, Sazinsky MH, Trifuoggi M, Di Donato A, Izzo V. Structural and functional insight into RHA-P, a bacterial GH106 α-L-rhamnosidase from Novosphingobium sp. PP1Y (2018) Arch. Biochem. Biophys, 648, 1-11. https://doi.org/10.1016/j.abb.2018.04.013
Mattossovich R., Iacono R., Cangiano G., Cobucci-Ponzano B., Isticato R., Moracci M., Ricca E. Conversion of xylan by recyclable spores of Bacillus subtilis displaying thermophilic enzymes (2017) Microbial Cell Factory 16, 218-226. DOI 10.1186/s12934-017-0833-3
D'Alonzo D, De Fenza M, Porto C, Iacono R, Huebecker M, Cobucci-Ponzano B, Priestman D, Platt FM, Parenti G, Moracci M, Palumbo G, Guaragna A. (2017) N-Butyl-L-Deoxynojirimycin (L-NBDNJ): Synthesis of an Allosteric Enhancer of α-Glucosidase Activity for the Treatment of Pompe Disease. J Med Chem. Nov 7. doi: 10.1021/acs.jmedchem.7b00646
Antranikian G, Suleiman M, Schäfers C, Adams MWW, Bartolucci S, Blamey JM, Birkeland NK, Bonch-Osmolovskaya E, da Costa MS, Cowan D, Danson M, Forterre P, Kelly R, Ishino Y, Littlechild J, Moracci M, Noll K, Oshima T, Robb F, Rossi M, Santos H, Schönheit P, Sterner R, Thauer R, Thomm M, Wiegel J, Stetter KO. (2017) Diversity of bacteria and archaea from two shallow marine hydrothermal vents from Vulcano Island. Extremophiles. 4, 733-742. doi: 10.1007/s00792-017-0938-y
Strazzulli A., Fusco S., Cobucci-Ponzano B., Moracci M and Contursi P. (2017). Metagenomics of microbial and viral life in terrestrial geothermal environments. Rev Environ Sci Biotechnol 16:425-454. doi:10.1007/s11157-017-9435-0.
Vecchio G., Parascandolo A., Allocca C., Ugolini C., Basolo F., Moracci M., Strazzulli A., Cobucci-Ponzano B., Laukkanen M.O., Castellone M.D., Tsuchida N. (2017) Human a-L-fucosidase-1 attenuates the invasive properties of thyroid cancer. Oncotarget. Vol. 8. doi: 10.18632/oncotarget.15635
Strazzulli A., Cobucci-Ponzano B., Carillo S., Bedini E., Corsaro M.M., Pocsfalvi G., Withers S.G., Rossi M., Moracci M*. (2017) Introducing transgalactosylation activity into a family 42 β-galactosidase. Glycobiology., 27, 425-437. doi: 10.1093/glycob/cwx013
Briggs DC, Yoshida-Moriguchi T, Zheng T, Venzke D, Anderson ME, Strazzulli A, Moracci M, Yu L, Hohenester E, Campbell KP. (2016) Structural basis of laminin binding to the LARGE glycans on dystroglycan. Nat Chem Biol. 12, 810-814, DOI 10.1038/nchembio.2146
Castiglia D, Sannino L, Marcolongo L, Ionata E, Tamburino R, De Stradis A, Cobucci-Ponzano B, Moracci M, La Cara F, Scotti N. (2016) High-level expression of thermostable cellulolytic enzymes in tobacco transplastomic plants and their use in hydrolysis of an industrially pretreated Arundo donax L. biomass. Biotechnol Biofuels. 9, 154
